Nonthyroidal illness syndrome (NTIS also known as low triiodothyronine syndrome or euthyroid sick syndrome) is also prevalent in SLE and characterized by decreased serum T3, normal to low thyroxine (T4), and thyroid-stimulating hormone (TSH) levels. Importantly, dyslipidemia is associated with disease activity (e.g., kidney damage and cardiovascular disease), and is closely related to the long-term prognosis of SLE patients. Dyslipidemia, characterized as increased total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and/or decreased high-density lipoprotein (HDL) levels in the serum, is prevalent in SLE patients with an incidence ranging between 18.1% and 75%. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production in women of childbearing age. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper.įunding: This study was supported by Nanjing Medical Science and Technique Development Foundation (Z.C., ZKX16039). Received: DecemAccepted: MaPublished: April 16, 2020Ĭopyright: © 2020 Zhang et al. PLoS ONE 15(4):Įditor: Deyu Fang, Northwestern University Feinberg School of Medicine, UNITED STATES (2020) Clinical significance of non-thyroidal illness syndrome on disease activity and dyslipidemia in patients with SLE. Citation: Zhang X, Liu L, Ma X, Hu W, Xu X, Huang S, et al.
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